Translating Electronic Currents to Precise Acetylcholine-Induced Neuronal Signaling Using an Organic Electrophoretic Delivery Device
نویسندگان
چکیده
Klas Tybrandt, Karin C Larsson, Sindhulakshmi Kurup, Daniel Simon, Peter Kjall, Joakim Isaksson, Mats Sandberg, Edwin Jager, Agneta Richter-Dahlfors and Magnus Berggren, Translating Electronic Currents to Precise Acetylcholine-Induced Neuronal Signaling Using an Organic Electrophoretic Delivery Device, 2009, Advanced Materials, (21), 44, 4442. http://dx.doi.org/10.1002/adma.200900187 Copyright: Wiley-VCH Verlag Berlin http://www.wiley-vch.de/publish/en/
منابع مشابه
An organic electronic biomimetic neuron enables auto-regulated neuromodulation.
Current therapies for neurological disorders are based on traditional medication and electric stimulation. Here, we present an organic electronic biomimetic neuron, with the capacity to precisely intervene with the underlying malfunctioning signalling pathway using endogenous substances. The fundamental function of neurons, defined as chemical-to-electrical-to-chemical signal transduction, is a...
متن کاملOrganic electronics for precise delivery of neurotransmitters to modulate mammalian sensory function.
Significant advances have been made in the understanding of the pathophysiology, molecular targets and therapies for the treatment of a variety of nervous-system disorders. Particular therapies involve electrical sensing and stimulation of neural activity, and significant effort has therefore been devoted to the refinement of neural electrodes. However, direct electrical interfacing suffers fro...
متن کاملModulation of the neuronal nicotinic acetylcholine receptor-channel by the nitromethylene heterocycle imidacloprid.
Nitromethylene heterocycle insecticides are known to act on the nicotinic acetylcholine receptor-channel. The effects of the nitromethylene heterocycle, imidacloprid, on the nicotinic acetylcholine receptor-channel of clonal rat phaeochromocytoma (PC12) cells were studied using whole-cell and single-channel patch clamp methods. Imidacloprid suppressed carbachol-induced whole-cell currents in a ...
متن کاملChemical delivery array with millisecond neurotransmitter release
Technologies that restore or augment dysfunctional neural signaling represent a promising route to deeper understanding and new therapies for neurological disorders. Because of the chemical specificity and subsecond signaling of the nervous system, these technologies should be able to release specific neurotransmitters at specific locations with millisecond resolution. We have previously demons...
متن کاملStable expression in HEK-293 cells of the rat c 3/134 subtype of neuronal nicotinic acetylcholine receptor
The tz31]~4 subtype of neuronal nicotinic acetylcholine receptor (nAChR) was stably expressed in human embryonic kidney (HEK) 293 cells that co-expressed a voltage-gated Ca 2+ channel. ¢z3/134-nAChR-expressing clones were identified using the fura-2 Ca 2÷ imaging technique, and were further characterised by single-cell and whole-cell patch-clamp studies. Acetylcholine (ACh) induced fast activat...
متن کامل